RNAi Experiment: MV_SV:mv_Y47D3B.7 |
Ace View of MV_SV:mv_Y47D3B.7
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Genes Inhibited |
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Gene Inhibited |
Y47D3B.7 (sbp-1) |
Description of "Y47D3B.7" |
sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; sbp-1 expression is detected exclusively in the intestine, the major site of fat storage, from early embryogenesis through adulthood. |
KOG Annotation  |
Predicted DNA-binding protein
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Evidence for Inhibition |
Sliding Window |
Raw score: 3066
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "Y47D3B.7" Links |
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MV_SV:mv_Y47D3B.7 Phenotypes |
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Embryonic |
Emb Penetrance None reported |
Larval |
Lva
penetrance is less than 90%
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Phenotype |
Unclassified
slim morphology
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MV_SV:mv_Y47D3B.7 Experiment Details |
Ace View |
Laboratory |
MV |
RNAi Reagent & Type |
mv_Y47D3B.7 (ORFeome_reagent) |
Remark |
bacterial-feeding RNAi began at the L1 larval stage |
Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-9-01 |
Gene Plot of Y47D3B.7 |
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