RNAi Experiment: MV_SV:mv_Y48G1A.d |
Ace View of MV_SV:mv_Y48G1A.d
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Genes Inhibited |
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Gene Inhibited |
Y48G1A.5 (imb-5) |
Description of "Y48G1A.5" |
imb-5 encodes an importin-beta-like protein orthologous to mammalian CAS proteins (cellular apoptosis susceptibility) and Saccharomyces cerevisiae CSE1 (chromosome segregation 1); IMB-5 is predicted to function in nuclear transport of proteins required for mitotic progression or apoptosis as well as in re-export of importin-alpha, a nuclear import protein; in C. elegans, IMB-5 is essential for embryogenesis and required for normal pronuclear envelope dynamics, and may also play a role in vulval morphogenesis. |
KOG Annotation  |
Nuclear export receptor CSE1/CAS (importin beta superfamily)
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Evidence for Inhibition |
Sliding Window |
Raw score: 1537
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "Y48G1A.5" Links |
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MV_SV:mv_Y48G1A.d Phenotypes |
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Embryonic |
Emb Penetrance None reported |
Larval |
Lva
phenotype observed among F1 progeny of treated animals
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Adult |
Sck
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Phenotype |
Unclassified
reduced brood size
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MV_SV:mv_Y48G1A.d Experiment Details |
Ace View |
Laboratory |
MV |
RNAi Reagent & Type |
mv_Y48G1A.d (ORFeome_reagent) |
Remark |
bacterial-feeding RNAi began at the L1 larval stage |
Reference |
Rual JF et al. (2004) Genome Res "Toward Improving Caenorhabditis elegans Phenome Mapping With an ORFeome-Based ...." |
Delivery Method |
Bacterial_feeding |
Date |
2004-9-01 |
Gene Plot of Y48G1A.5 |
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