| RNAi Experiment: PF:GL1_1A3 |
Ace View of PF:GL1_1A3
|
| Genes Inhibited |
 |
| Gene Inhibited |
C52D10.9 (skr-8) |
| Description of "C52D10.9" |
skr-8 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-8 is required for is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-8 can interact with CUL-1, a C. elegans cullin homolog. |
| KOG Annotation |
SCF ubiquitin ligase, Skp1 component
|
|
| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (IV:17164865..17165928)
Transcript overlap: 665 nt |
|
| Sliding Window |
Raw score: 644
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.588 |
| Wormbase (BLAST) |
RNAi primary |
|
| External "C52D10.9" Links |
  |
| Gene Inhibited |
Y105C5B.13 (skr-10) |
| Description of "Y105C5B.13" |
skr-10 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-10 is required for posterior body morphogenesis, embryonic and larval development, and cell proliferation; SKR-10 is expressed in the tip and end regions of the intestine and can interact in vivo with CUL-1 and CUL-2, C. elegans cullin homologs. |
| KOG Annotation |
SCF ubiquitin ligase, Skp1 component
|
|
| Evidence for Inhibition |
| Sliding Window |
Raw score: 129
Relative score: 0.2 (Best raw score= for Gene )
Specificity index: 0.118 |
| Wormbase (BLAST) |
RNAi secondary |
|
| External "Y105C5B.13" Links |
|
| Gene Inhibited |
C52D10.7 (skr-9) |
| Description of "C52D10.7" |
skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation. |
| KOG Annotation |
SCF ubiquitin ligase, Skp1 component
|
|
| Evidence for Inhibition |
| Sliding Window |
Raw score: 323
Relative score: 0.502 (Best raw score= for Gene )
Specificity index: 0.295 |
| Wormbase (BLAST) |
RNAi primary |
|
| External "C52D10.7" Links |
|
| PF:GL1_1A3 Phenotypes |
|
|
| Embryonic |
Emb Penetrance 15 - 40 % |
| Larval |
Gro
Observed in >=10% of progeny.
Lva
Observed in >=10% of progeny.
|
| Adult |
Bmd
Observed in <10% of progeny.
Ste
|
| PF:GL1_1A3 Experiment Details |
Ace View |
| Laboratory |
KK |
| RNAi Reagent & Type |
sjj_C52D10.9 (PCR_reagent) |
| Remark |
PCR product contains flanking T7 promoter sequences |
| Reference |
Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans" |
| Delivery Method |
Injection |
| Date |
2002-11-19 |
| Gene Plot of Y105C5B.13 |
Browse using GBrowse
|
 |
| Gene Plot of C52D10.7 |
Browse using GBrowse
|
 |
| Gene Plot of C52D10.9 |
Browse using GBrowse
|
 |
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