Link to K05C4.6Link to K05C4.5.1Link to K05C4.5.2RNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
RNAi Experiment: PF:GL1_1G12 Ace View of PF:GL1_1G12
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K05C4.6 (hmp-2)
Description of "K05C4.6"  hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway.
KOG Annotation  Armadillo/beta-Catenin/plakoglobin
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:14740807..14741923)
Transcript overlap: 977 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 956
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K05C4.6" Links  Wormbase NCBI
PF:GL1_1G12 Phenotypes Run Phenoblast! Run Phenoblast Help with Phenotypes
Embryonic  Emb Penetrance 80 - 100 %
Adult  Dpy Observed in >=10% of progeny.
Rup Observed in <10% of progeny.
Phenotype  Aberrant AB or P1 spindle orientation
Division axis of ABa or ABp aberrant
EMS fails to extend anteriorly
Exaggerated pseudocleavage
Multiple cavities
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif Help
PF:GL1_1G12 Experiment Details Ace View
Laboratory  KK
RNAi Reagent & Type  sjj_K05C4.6 (PCR_reagent)
Remark  PCR product contains flanking T7 promoter sequences
Reference  Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Delivery Method  Injection
Date  2002-11-19
Gene Plot of K05C4.6 Browse using GBrowse
Gene Graph