Link to R06C7.8Link to R06C7.9RNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentgeneMap
Go to RNAiDB Home Adult Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie Wild-type C. elegans Movie
 
RNAi Experiment: PF:GL1_2F2 Ace View of PF:GL1_2F2
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  R06C7.8 (bub-1)
Description of "R06C7.8"  bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages.
KOG Annotation  Mitotic checkpoint serine/threonine protein kinase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:7253627..7254668)
Transcript overlap: 953 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 890
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "R06C7.8" Links  Wormbase NCBI
PF:GL1_2F2 Phenotypes Run Phenoblast! Run Phenoblast Help with Phenotypes
Embryonic  Emb Penetrance 100 %
Phenotype  Multiple cavities
Movies/Stacks/Images  /static/images/movie.gif /static/images/movie.gif /static/images/movie.gif Help
PF:GL1_2F2 Experiment Details Ace View
Laboratory  KK
RNAi Reagent & Type  sjj_R06C7.8 (PCR_reagent)
Remark  PCR product contains flanking T7 promoter sequences
Reference  Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Delivery Method  Injection
Date  2002-11-19
Gene Plot of R06C7.8 Browse using GBrowse
Gene Graph