RNAi Experiment: PF:GL1_2F2 |
Ace View of PF:GL1_2F2
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Genes Inhibited |
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Gene Inhibited |
R06C7.8 (bub-1) |
Description of "R06C7.8" |
bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages. |
KOG Annotation  |
Mitotic checkpoint serine/threonine protein kinase
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (I:7253627..7254668)
Transcript overlap: 953 nt |
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Sliding Window |
Raw score: 890
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "R06C7.8" Links |
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PF:GL1_2F2 Phenotypes |
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Embryonic |
Emb Penetrance 100 % |
Phenotype |
Multiple cavities
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Movies/Stacks/Images |
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PF:GL1_2F2 Experiment Details |
Ace View |
Laboratory |
KK |
RNAi Reagent & Type |
sjj_R06C7.8 (PCR_reagent) |
Remark |
PCR product contains flanking T7 promoter sequences |
Reference |
Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans" |
Delivery Method |
Injection |
Date |
2002-11-19 |
Gene Plot of R06C7.8 |
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