| Ace View of PF:GL1_2G3 | |||||||||
| Gene Inhibited | K08E3.6 (cyk-4) | ||||||||
| Description of "K08E3.6" | cyk-4 encodes a GTPase activating protein (GAP) for the Rho family of GTPases that, together with ZEN-4, is sufficient to promote the formation of the large bundles of microtubules that form the central spindle during anaphase, and is required for fertility and coordinated locomotion postembryonically; localizes to the central spindle during anaphase interdependently with ZEN-4, and interacts with ZEN-4 in vitro and in vivo. | ||||||||
| KOG Annotation | GTPase-activating protein |
||||||||
| Evidence for Inhibition |
|
||||||||
| External "K08E3.6" Links |   |
||||||||
| Embryonic | Emb Penetrance 80 - 100 % | ||||||||
| Phenotype | Cytokinesis defect Ectopic cleavage furrows Multiple nuclei in 1, 2, or 4-cell embryos P0 spindle positioning defect Pronuclear breakdown asynchronous Pronuclei fail to migrate Pronuclei meet more centrally Pseudocleavage absent |
||||||||
| Movies/Stacks/Images |  |
||||||||
| Laboratory | KK | ||||||||
| RNAi Reagent & Type | sjj_K08E3.6 (PCR_reagent) | ||||||||
| Remark | PCR product contains flanking T7 promoter sequences | ||||||||
| Reference | Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans" | ||||||||
| Delivery Method | Injection | ||||||||
| Date | 2002-11-19 | ||||||||
| Gene Plot of K08E3.6 | |||||||||
 |
|||||||||
![Adult](JavaScript:void
window.open("/cgi-bin/rnaidb/popUpImage.cgi?imgName=N2wormfinal.png",
"RNAiDB Help","toolbar=no, location=no, directories=no,
status=no, menubar=no, scrollbars=yes, resizable=no,
copyhistory=no, width=1000, height=550"))
 |
Please provide feedback if you are experiencing any difficulties with this website. |