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RNAi Experiment: PF:GL1_3E8 Ace View of PF:GL1_3E8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C48E7.3 (lpd-2)
Description of "C48E7.3"  lpd-2 encodes a predicted transcription factor with homology to transcription factors of the CCAAT/Enhancer Binding Protein family (C/EBPA and B, OMIM:116897, 189965, associated with the regulation of mammalian adipocyte differentiation); in C. elegans, LPD-2 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for larval development; in addition, LPD-2 may be part of a conserved pathway regulating lipogenesis, as LPD-2 appears to positively regulate expression of sbp-1, which encodes the C. elegans Sterol Regulatory Element Binding Protein (SREBP) homolog, a basic helix-loop-helix-type transcription factor also required for normal lipid metabolism and larval development.
KOG Annotation  Protein involved in rRNA processing
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:6253725..6254822)
Transcript overlap: 915 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 810
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C48E7.3" Links  Wormbase NCBI
PF:GL1_3E8 Phenotypes Help with Phenotypes
Larval  Gro Observed in >=10% of progeny.
Lva Observed in >=10% of progeny.
Adult  Ste
PF:GL1_3E8 Experiment Details Ace View
Laboratory  KK
RNAi Reagent & Type  sjj_C48E7.3 (PCR_reagent)
Remark  PCR product contains flanking T7 promoter sequences
Reference  Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Delivery Method  Injection
Date  2002-11-19
Gene Plot of C48E7.3 Browse using GBrowse
Gene Graph