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RNAi Experiment: PF:GL1_4C3 Ace View of PF:GL1_4C3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  ZK381.1 (him-3)
Description of "ZK381.1"  him-3 encodes a homolog of the S. cerevisiae HOP1 protein which is required for the formation of the synaptonemal complex during meiosis; him-3 is required for synapsis and chiasma formation during meiotic recombination and for chromosome segregation; him-3 mutants show a high frequency of males in the population as well as a high frequency of arrested embryos due to defects in X-chromosome segregation; HIM-3 localizes to the meiotic chromosome associating with both unsynapsed and synapsed chromosomes.
KOG Annotation  HORMA domain
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (IV:6977584..6978619)
Transcript overlap: 901 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 817
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "ZK381.1" Links  Wormbase NCBI
PF:GL1_4C3 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 30 %
Adult  Him >0.4% male progeny observed.
PF:GL1_4C3 Experiment Details Ace View
Laboratory  KK
RNAi Reagent & Type  sjj_ZK381.1 (PCR_reagent)
Remark  PCR product contains flanking T7 promoter sequences
Reference  Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans"
Delivery Method  Injection
Date  2002-11-19
Gene Plot of ZK381.1 Browse using GBrowse
Gene Graph