Ace View of PF:GL1_6E10 | |||
Gene Inhibited | C55B7.8 (dbr-1) | ||
Description of "C55B7.8" | dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels. | ||
KOG Annotation  | RNA lariat debranching enzyme |
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Evidence for Inhibition | |||
External "C55B7.8" Links | |||
Embryonic | Emb Penetrance 25 - 55 % | ||
Larval | Gro
Observed in >=10% of progeny. |
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Adult | Stp
Observed in <10% of progeny. Pleiotropic |
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Laboratory | KK | ||
RNAi Reagent & Type | sjj_C55B7.8 (PCR_reagent) | ||
Remark | PCR product contains flanking T7 promoter sequences | ||
Reference | Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans" | ||
Delivery Method | Injection | ||
Date | 2002-11-19 | ||
Gene Plot of C55B7.8 | |||