| Ace View of PF:GL1_6F11 | |||||||||
| Gene Inhibited | K07C11.2 (air-1) | ||||||||
| Description of "K07C11.2" | AIR-1 belongs to the Aurora-A family of serine/threonine kinases that localize to centrosomes; AIR-1 is required for embryonic survival, germline proliferation and development, locomotion, and vulval development; AIR-1 is required to recruit centrosomal gamma-tubulin during maturation; Aurora-A kinases are implicated in centrosome separation and spindle assembly. | ||||||||
| KOG Annotation | Serine/threonine protein kinase |
||||||||
| Evidence for Inhibition |
|
||||||||
| External "K07C11.2" Links |   |
||||||||
| Gene Inhibited | K07C11.9 | ||||||||
| KOG Annotation | Uncharacterized conserved protein |
||||||||
| Evidence for Inhibition |
|
||||||||
| External "K07C11.9" Links | |
||||||||
| Embryonic | Emb Penetrance 80 - 100 % | ||||||||
| Phenotype | Aberrant AB or P1 spindle orientation Cytokinesis defect Ectopic cleavage furrows Exaggerated pseudocleavage Excessive blebbing Multiple nuclei in 1, 2, or 4-cell embryos P0 spindle positioning defect Polar bodies abnormal Pronuclei meet more centrally Synchronous second division |
||||||||
| Movies/Stacks/Images |  |
||||||||
| Laboratory | KK | ||||||||
| RNAi Reagent & Type | sjj_K07C11.2 (PCR_reagent) | ||||||||
| Remark | PCR product contains flanking T7 promoter sequences | ||||||||
| Reference | Piano et al. (2002) Curr Biol "Gene Clustering Based on RNAi Phenotypes of Ovary-Enriched Genes in C. elegans" | ||||||||
| Delivery Method | Injection | ||||||||
| Date | 2002-11-19 | ||||||||
| Gene Plot of K07C11.9 | |||||||||
 |
|||||||||
| Gene Plot of K07C11.2 | |||||||||
 |
|||||||||
![Adult](JavaScript:void
window.open("/cgi-bin/rnaidb/popUpImage.cgi?imgName=N2wormfinal.png",
"RNAiDB Help","toolbar=no, location=no, directories=no,
status=no, menubar=no, scrollbars=yes, resizable=no,
copyhistory=no, width=1000, height=550"))
 |
Please provide feedback if you are experiencing any difficulties with this website. |