RNAi Experiment: PF:ORC_4A3 |
Ace View of PF:ORC_4A3
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Genes Inhibited |
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Gene Inhibited |
C47D12.8 |
Description of "C47D12.8" |
C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3. |
KOG Annotation  |
Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4
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Evidence for Inhibition |
Sliding Window |
Raw score: 1014
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
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External "C47D12.8" Links |
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PF:ORC_4A3 Phenotypes |
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Embryonic |
Emb Penetrance 100 - 100 % |
Movies/Stacks/Images |
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PF:ORC_4A3 Experiment Details |
Ace View |
Laboratory |
PF |
RNAi Reagent & Type |
mv_VF13D12L.2 (ORFeome_reagent) |
Strain |
N2 |
Delivery Method |
Soaking |
Gene Plot of C47D12.8 |
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