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RNAi Experiment: PF:ORC_8E3 Ace View of PF:ORC_8E3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K04F10.6 (rde-3)
Description of "K04F10.6"  rde-3 encodes a nucleotidyltransferase that is a member of the polymerase beta nucleotidyltransferase superfamily that includes poly(A) polymerases, 2-5 oligoadenylate synthetases, C. elegans GLD-2, and S. cerevisiae Trf4p; by homology, RDE-3 is predicted to function as a poly(A) polymerase whose activity is required for meiotic chromosome segregation, negative regulation of DNA transposition, non-transgene-induced RNAi (i.e. RNAi via feeding is affected, whereas RNAi via expression of sense and antisense RNA from a transgene is not), fertility, and viability; analysis of siRNA levels in rde-3 mutant animals indicates that during RNAi, RDE-3 activity is required at a point upstream of siRNA accumulation; neither the precise mechanistic role of RDE-3 in posttranscriptional silencing, nor the RDE-3 expression pattern, is yet known.
Evidence for Inhibition 
Sliding Window Raw score: 1247
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
External "K04F10.6" Links  Wormbase NCBI
PF:ORC_8E3 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 95 - 95 %
Adult  Ste
PF:ORC_8E3 Experiment Details Ace View
Laboratory  PF
RNAi Reagent & Type  mv_K04F10.6 (ORFeome_reagent)
Strain  N2
Delivery Method  Soaking
Gene Plot of K04F10.6 Browse using GBrowse
Gene Graph