Description of "F45H11.4" |
mgl-2 encodes a Group I metabotropic glutamate receptor (OMIM:604473, 604102, loss-of-function mutations in mice are associated with defects in long-term potentiation); by homology, MGL-2 is predicted to function as a post-synaptic G protein-coupled receptor that, in response to glutamate binding, stimulates phospholipase C activity and increases neuronal excitation, and in mammalian tissue culture cells, glutamate stimulation of MGL-2 does result in increased phosphoinositide turnover; a mutation in mgl-2 indicates that it is required for normal head movements and tap reversal reflexes, while loss of mgl-2 activity via large-scale RNAi screens indicates that MGL-2 is also required for embryogenesis; a mgl-2::GFP reporter is expressed in interneurons. |