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RNAi Experiment: SA:yk271a8 Ace View of SA:yk271a8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C29E4.3 (ran-2)
Description of "C29E4.3"  ran-2 encodes the C. elegans RanGAP (GTPase activating protein) homolog, conserved amongst yeast, Drosophila (segregation distorter), Xenopus, and humans; by homology, RAN-2 is predicted to function as a key regulator of the Ran GTP/GDP cycle by stimulating the otherwise weak Ran GTPase activity; in C. elegans, RAN-2 activity is essential during early embryogenesis for comigration of centrosomes with the male pronucleus, mitotic spindle formation, chromosome segregation, and nuclear envelope assembly; in addition, RAN-2 is also required for nucleocytoplasmic transport; ran-2 reporter gene expression is detected in embryos and larvae, although the precise subcellular localization is not yet known.
KOG Annotation  Ran GTPase-activating protein
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 2337
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C29E4.3" Links  Wormbase NCBI
SA:yk271a8 Phenotypes Help with Phenotypes
Adult  Ste
SA:yk271a8 Experiment Details Ace View
Laboratory  SA
RNAi Reagent & Type  yk271a8 (cDNA_reagent)
Remark  yk271a8
Reference  Maeda I et al. (2001) Current Biology "Large-scale analysis of gene function in Caenorhabditis elegans by ...."
Date  2001-2-06
Gene Plot of C29E4.3 Browse using GBrowse
Gene Graph