Link to F53G12.3RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentLink to F56C11.1geneMap Link to F56C11.1RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentLink to F53G12.3geneMap
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RNAi Experiment: SA:yk296c2 Ace View of SA:yk296c2
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F53G12.3
Description of "F53G12.3"  F53G12.3 encodes a large partial homolog of dual oxidase ('Ce-Duox2'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; F53G12.3 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; F53G12.3 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; F53G12.3 has no visible expression pattern detectable by antibodies, implying very low or rare expression.
KOG Annotation  Ferric reductase, NADH/NADPH oxidase and related proteins
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 662
Relative score: 0.281 (Best raw score= for Gene )
Specificity index: 0.22
External "F53G12.3" Links  Wormbase NCBI
Gene Inhibited  F56C11.1 (bli-3)
Description of "F56C11.1"  bli-3 encodes a large homolog of dual oxidase ('Ce-Duox1'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis.
KOG Annotation  Ferric reductase, NADH/NADPH oxidase and related proteins
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 2352
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.78
Wormbase (BLAST) RNAi primary
External "F56C11.1" Links  Wormbase NCBI
SA:yk296c2 Phenotypes Help with Phenotypes
Adult  Dpy
SA:yk296c2 Experiment Details Ace View
Laboratory  SA
RNAi Reagent & Type  yk296c2 (cDNA_reagent)
Remark  yk296c2
Reference  Maeda I et al. (2001) Current Biology "Large-scale analysis of gene function in Caenorhabditis elegans by ...."
Date  2001-2-06
Gene Plot of F56C11.1 Browse using GBrowse
Gene Graph
Gene Plot of F53G12.3 Browse using GBrowse
Gene Graph