RNAi Experiment: SA:yk296c2 |
Ace View of SA:yk296c2
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Genes Inhibited |
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Gene Inhibited |
F53G12.3 |
Description of "F53G12.3" |
F53G12.3 encodes a large partial homolog of dual oxidase ('Ce-Duox2'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; F53G12.3 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; F53G12.3 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; F53G12.3 has no visible expression pattern detectable by antibodies, implying very low or rare expression. |
KOG Annotation  |
Ferric reductase, NADH/NADPH oxidase and related proteins
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Evidence for Inhibition |
Sliding Window |
Raw score: 662
Relative score: 0.281 (Best raw score= for Gene )
Specificity index: 0.22 |
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External "F53G12.3" Links |
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Gene Inhibited |
F56C11.1 (bli-3) |
Description of "F56C11.1" |
bli-3 encodes a large homolog of dual oxidase ('Ce-Duox1'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; BLI-3 is required for dityrosine cross-linking of collagen, and thus for cuticular integrity; BLI-3 is thought to use cytosolic NADPH to generate reactive oxygen, which then drives the peroxidase ectodomain to cross-link free tyrosine in collagen; BLI-3 is expressed exclusively in hypodermal cells at low levels, with peaks of expression corresponding to collagen/cuticle biosynthesis. |
KOG Annotation  |
Ferric reductase, NADH/NADPH oxidase and related proteins
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Evidence for Inhibition |
Sliding Window |
Raw score: 2352
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.78 |
Wormbase (BLAST) |
RNAi primary |
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External "F56C11.1" Links |
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SA:yk296c2 Phenotypes |
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Adult |
Dpy
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SA:yk296c2 Experiment Details |
Ace View |
Laboratory |
SA |
RNAi Reagent & Type |
yk296c2 (cDNA_reagent) |
Remark |
yk296c2 |
Reference |
Maeda I et al. (2001) Current Biology "Large-scale analysis of gene function in Caenorhabditis elegans by ...." |
Date |
2001-2-06 |
Gene Plot of F56C11.1 |
Browse using GBrowse
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Gene Plot of F53G12.3 |
Browse using GBrowse
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