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RNAi Experiment: SA:yk342e7 Ace View of SA:yk342e7
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  W02B9.1 (hmr-1)
Description of "W02B9.1"  hmr-1 encodes two isoforms of a classical cadherin that contain extracellular cadherin, EGF-like, and laminin G domains as well as a highly conserved intracellular domain that binds beta-catenin; by homology, the HMR-1 proteins are predicted to function as calcium-dependent, homophilic cell-cell adhesion receptors; in vivo, HMR-1A activity is required for mediating the cell migrations, cell shape changes, and presumably actin cytoskeleton rearrangements that occur during embryonic morphogenesis; HMR-1B is required for fasciculation and outgrowth of a subset of motor neuron processes; HMR-1 antibodies detect expression in all embryonic blastomeres at early stages of development but as hypodermal adherens junctions form and morphogenesis begins, HMR-1 becomes highly expressed in the apical junctions of all hypodermal cells; later, HMR-1 is expressed primarily at the apical margins of hypodermal, pharyngeal, and intestinal cells in a pattern consistent with localization to adherens junctions; an HMR-1B reporter fusion is expressed in neurons, including the DD, VD, and AS class of motor neurons; HMR-1 activity is required for proper localization of other junctional components, such as HMP-1/alpha-catenin and HMP-2/beta-catenin, but not for localization of AJM-1, the junctional component recognized by the MH27 antibody.
KOG Annotation  Cadherin repeats
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 955
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "W02B9.1" Links  Wormbase NCBI
SA:yk342e7 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 71 %
SA:yk342e7 Experiment Details Ace View
Laboratory  SA
RNAi Reagent & Type  yk342e7 (cDNA_reagent)
Remark  yk342e7
Reference  Maeda I et al. (2001) Current Biology "Large-scale analysis of gene function in Caenorhabditis elegans by ...."
Date  2001-2-06
Gene Plot of W02B9.1 Browse using GBrowse
Gene Graph