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RNAi Experiment: SA:yk358c9 Ace View of SA:yk358c9
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K04G2.8 (apr-1)
Description of "K04G2.8"  The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39.
KOG Annotation  Beta-catenin-binding protein APC, contains ARM repeats
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 2125
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K04G2.8" Links  Wormbase NCBI
SA:yk358c9 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 90 %
Larval  Lva
Adult  Unc
SA:yk358c9 Experiment Details Ace View
Laboratory  SA
RNAi Reagent & Type  yk358c9 (cDNA_reagent)
Remark  yk358c9
Reference  Maeda I et al. (2001) Current Biology "Large-scale analysis of gene function in Caenorhabditis elegans by ...."
Date  2001-2-06
Gene Plot of K04G2.8 Browse using GBrowse
Gene Graph