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RNAi Experiment: Simmer:B0336.6 Ace View of Simmer:B0336.6
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  B0336.6
Description of "B0336.6"  B0336.6 encodes an Abl interactor ortholog, with an SH3 domain, required for embryonic development; mammalian Abl interactors are associated with synaptosomes, growth cone particles, and macropinocytic vesicles, and may regulate Rac-dependent cytoskeletal reorganization and Abl kinase activity; B0336.6's orthologs include human SSH3BP1 (ABI1; OMIM:603050, mutated in acute myeloid leukemia), ABI-2 (OMIM:606442), and NESH (OMIM:606363); B0336.6 binds UNC-53 in two-hybrid screens.
KOG Annotation  Abl interactor ABI-1, contains SH3 domain
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:5690942..5692588)
Transcript overlap: 1063 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 979
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "B0336.6" Links  Wormbase NCBI
Simmer:B0336.6 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 100 %
Adult  Pvl
Stp
Unc
Simmer:B0336.6 Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_B0336.6 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of B0336.6 Browse using GBrowse
Gene Graph