RNAi Experiment: Simmer:B0547.1 |
Ace View of Simmer:B0547.1
|
Genes Inhibited |
|
Gene Inhibited |
B0547.1 (csn-5) |
Description of "B0547.1" |
csn-5 encodes an ortholog of subunit 5 of the COP9 signalosome complex (CSN5), which in turn is a pan-eukaryotic multiprotein complex that positively regulates E3 ubiquitin ligases, physically interacts with SCF-type E3 ubiquitin ligases, and probably regulates protein degradation; CSN-5 (along with KGB-1 and ZYX-1) physically binds germline RNA helicases (GLH proteins), and csn-5(RNAi) results in sterile worms with small gonads and no oocytes, causing oogenesis to cease, but not affecting the initial assembly of P granules -- a defect essentially identical to that produced by RNAi with a combination of glh-1 and glh-4. |
KOG Annotation  |
COP9 signalosome, subunit CSN5
|
|
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (IV:5649987..5651016)
Transcript overlap: 784 nt |
|
Sliding Window |
Raw score: 742
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
|
External "B0547.1" Links |
|
Simmer:B0547.1 Phenotypes |
|
|
Embryonic |
Emb Penetrance 50 - 80 % |
Simmer:B0547.1 Experiment Details |
Ace View |
Laboratory |
NL |
RNAi Reagent & Type |
sjj_B0547.1 (PCR_reagent) |
Strain |
NL4256 rrf-3(pk1426) |
Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
Date |
2003-10-01 |
Gene Plot of B0547.1 |
Browse using GBrowse
|
|