Ace View of Simmer:C10H11.9:Screen_A | |||
Gene Inhibited | C10H11.9 (let-502) | ||
Description of "C10H11.9" | let-502 encodes Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase), and is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization. | ||
KOG Annotation  | Rho-associated, coiled-coil containing protein kinase |
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Evidence for Inhibition | |||
External "C10H11.9" Links | |||
Embryonic | Emb Penetrance 100 % | ||
Adult | Bmd Dpy Ste brood size (1 out of 5) |
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Phenotype | Rol |
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Laboratory | NL | ||
RNAi Reagent & Type | sjj_C10H11.9 (PCR_reagent) | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Date | 2003-10-01 | ||
Gene Plot of C10H11.9 | |||