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RNAi Experiment: Simmer:C10H11.9:Screen_B Ace View of Simmer:C10H11.9:Screen_B
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C10H11.9 (let-502)
Description of "C10H11.9"  let-502 encodes Rho-binding Ser/Thr kinase orthologous to human myotonic dystrophy kinase (DM-kinase), and is required for early embryonic cleavages, embryonic elongation, migration of hypodermal P cells to a ventral position, normal spermathecal contraction, and fertility; LET-502 is required for hypodermal cells to properly change their shape, and is expressed in those cells, during embryonic elongation; let-502 mutations are suppressed by mel-11 mutations, and the pattern of LET-502 expression in the embryonic epidermis and the spermatheca is opposite to that of MEL-11, indicating that LET-502 and MEL-11 have opposing functions (presumably tissue contraction and relaxation); MEL-11 requires LET-502 (along with the nonmuscle myosin NMY-1) for proper localization.
KOG Annotation  Rho-associated, coiled-coil containing protein kinase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:4742449..4743523)
Transcript overlap: 800 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 738
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C10H11.9" Links  Wormbase NCBI
Simmer:C10H11.9:Screen_B Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 20 - 40 %
Larval  Lva
Adult  Bmd
Simmer:C10H11.9:Screen_B Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_C10H11.9 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of C10H11.9 Browse using GBrowse
Gene Graph