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RNAi Experiment: Simmer:C12C8.3:Screen_B Ace View of Simmer:C12C8.3:Screen_B
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C12C8.3 (lin-41)
Description of "C12C8.3"  The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates.
KOG Annotation  Predicted E3 ubiquitin ligase
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:9336218..9337334)
Transcript overlap: 1025 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 962
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C12C8.3" Links  Wormbase NCBI
Simmer:C12C8.3:Screen_B Phenotypes Help with Phenotypes
Adult  Rup
Sma
Ste brood size (6 out of 10)
Stp
Phenotype  Adl
Simmer:C12C8.3:Screen_B Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_C12C8.3 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of C12C8.3 Browse using GBrowse
Gene Graph