RNAi Experiment: Simmer:C14A4.4 |
Ace View of Simmer:C14A4.4
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Genes Inhibited |
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Gene Inhibited |
C14A4.4 (crn-3) |
Description of "C14A4.4" |
crn-3 encodes a cell death-related nuclease, homologous to the 100 kDa polymyositis/scleroderma autoantigen (PM/Scl-100), that is required for normal levels of DNA degradation during apoptosis; PM/Scl-100 is a ribonuclease component of the multiexonuclease exosome complex, which processes or degrades several types of RNAs in yeast; crn-3(RNAi) animals show retarded growth and a low penetrance of embryonic lethality; CRN-3 promotes both DNA degradation and cell corpse engulfment, in a partially redundant pathway that includes CRN-2 but is parallel to CPS-6; CRN-3 is predicted to be mitochondrial. |
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (II:10588741..10589775)
Transcript overlap: 957 nt |
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Sliding Window |
Raw score: 936
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "C14A4.4" Links |
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Simmer:C14A4.4 Phenotypes |
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Larval |
Lva
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Simmer:C14A4.4 Experiment Details |
Ace View |
Laboratory |
NL |
RNAi Reagent & Type |
sjj_C14A4.4 (PCR_reagent) |
Strain |
NL4256 rrf-3(pk1426) |
Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
Date |
2003-10-01 |
Gene Plot of C14A4.4 |
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