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RNAi Experiment: Simmer:C36E8.5 Ace View of Simmer:C36E8.5
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C36E8.5 (tbb-2)
Description of "C36E8.5"  tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis.
KOG Annotation  Beta tubulin
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:4016654..4017548)
Transcript overlap: 746 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 641
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C36E8.5" Links  Wormbase NCBI
Simmer:C36E8.5 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 100 %
Simmer:C36E8.5 Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_C36E8.5 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of C36E8.5 Browse using GBrowse
Gene Graph