Link to C39F7.1RNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentgeneMap Link to C39F7.1Link to C39F7.4.1Link to C39F7.4.2RNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAiRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentRNAi ReagentLink to K09A9.2.2Link to K09A9.2.1geneMap
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RNAi Experiment: Simmer:C39F7.1:Screen Ace View of Simmer:C39F7.1:Screen
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C39F7.1
Evidence for Inhibition 
ePCR Status: Best_ePCR (V:1261549..1262543)
Transcript overlap: 726 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 684
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.914
Wormbase (BLAST) RNAi primary
External "C39F7.1" Links  Wormbase NCBI
Gene Inhibited  C39F7.4 (rab-1)
Description of "C39F7.4"  rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline.
KOG Annotation  GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Bottom50_percentile_ePCR (V:1261549..1262543)
Transcript overlap: 85 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 64
Relative score: 0.094 (Best raw score= for Gene )
Specificity index: 0.086
External "C39F7.4" Links  Wormbase NCBI
Simmer:C39F7.1:Screen Phenotypes Help with Phenotypes
Larval  Gro could not be confirmed by re-testing
Adult  Dpy could not be confirmed by re-testing
Unc could not be confirmed by re-testing
Phenotype  Prz could not be confirmed by re-testing
Simmer:C39F7.1:Screen Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_C39F7.1 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of C39F7.1 Browse using GBrowse
Gene Graph
Gene Plot of C39F7.4 Browse using GBrowse
Gene Graph