RNAi Card Page

RNAi Experiment: Simmer:C39F7.4

Genes Inhibited

Gene Inhibited

Description of "C39F7.4"

rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline.

KOG Annotation

GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins

Evidence for Inhibition

ePCR	Status: Unique_ePCR (V:1262845..1263838) Transcript overlap: 712 nt
Sliding Window	Raw score: 586 Relative score: 1 (This gene has the best score for this RNAi reagent) Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST)	RNAi primary