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RNAi Experiment: Simmer:C45G3.1:Screen_B Ace View of Simmer:C45G3.1:Screen_B
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C45G3.1 (tag-255)
Description of "C45G3.1"  The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion.
KOG Annotation  Microtubule-associated protein Asp
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:9223777..9224942)
Transcript overlap: 1120 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1078
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C45G3.1" Links  Wormbase NCBI
Simmer:C45G3.1:Screen_B Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 50 - 80 %
Larval  Gro
Adult  Pvl
Simmer:C45G3.1:Screen_B Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_C45G3.1 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of C45G3.1 Browse using GBrowse
Gene Graph