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RNAi Experiment: Simmer:C47E8.7 Ace View of Simmer:C47E8.7
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C47E8.7 (unc-112)
Description of "C47E8.7"  The unc-112 gene encodes a pleckstrin homology domain-containing protein, orthologous to human Mitogen inducible gene-2, that is required for assembly of muscle dense bodies and M lines during embryogenesis; UNC-112 is a dense body/M-line component and requires PAT-3/beta-integrin, UNC-52/perlecan, and PAT-4/integrin-linked kinase for proper localization; UNC-112 binds PAT-4 directly, forms a ternary complex with PAT-4 and PAT-6/actopaxin, and is required for recruitment of PAT-3 and PAT-4 to muscle cell attachment sites; viable unc-112 mutations are suppressed by mutation of dim-1.
KOG Annotation  Mitogen inducible gene product (contains ERM and PH domains)
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (V:14696192..14697281)
Transcript overlap: 961 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 921
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C47E8.7" Links  Wormbase NCBI
Simmer:C47E8.7 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 100 %
Simmer:C47E8.7 Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_C47E8.7 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of C47E8.7 Browse using GBrowse
Gene Graph