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RNAi Experiment: Simmer:C55B7.8:Screen_A Ace View of Simmer:C55B7.8:Screen_A
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  C55B7.8 (dbr-1)
Description of "C55B7.8"  dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels.
KOG Annotation  RNA lariat debranching enzyme
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:6491583..6492683)
Transcript overlap: 883 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 799
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "C55B7.8" Links  Wormbase NCBI
Simmer:C55B7.8:Screen_A Phenotypes Help with Phenotypes
Larval  Gro
Adult  Unc
Phenotype  Unclassified Thin
Simmer:C55B7.8:Screen_A Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_C55B7.8 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of C55B7.8 Browse using GBrowse
Gene Graph