| Ace View of Simmer:D2045.6 | |||||||||
| Gene Inhibited | D2045.6 (cul-1) | ||||||||
| Description of "D2045.6" | cul-1 encodes a cullin, orthologous to Cdc53/Cul1 in S. cerevisiae and CUL-1 in humans (OMIM:603134), that is required both maternally and zygotically for developmentally programmed transitions from the G1 phase of the cell cycle to the GO phase or the apoptotic pathway, and that is probably also required for normally slow G1-to-S phase progression; CUL-1 physically interacts with eight Skp1-related proteins (SKR-1, -2, -3, -4, -7, -8, -9, and -10). | ||||||||
| KOG Annotation | Cullins |
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| Evidence for Inhibition |
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| External "D2045.6" Links |   |
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| Embryonic | Emb Penetrance 100 % | ||||||||
| Laboratory | NL | ||||||||
| RNAi Reagent & Type | sjj_D2045.6 (PCR_reagent) | ||||||||
| Strain | NL4256 rrf-3(pk1426) | ||||||||
| Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||||||||
| Date | 2003-10-01 | ||||||||
| Gene Plot of D2045.6 | |||||||||
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