RNAi Experiment: Simmer:F12F6.6 |
Ace View of Simmer:F12F6.6
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Genes Inhibited |
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Gene Inhibited |
F12F6.6 (sec-24.1) |
Description of "F12F6.6" |
sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis. |
KOG Annotation  |
Vesicle coat complex COPII, subunit SFB3
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (IV:11562315..11563492)
Transcript overlap: 1132 nt |
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Sliding Window |
Raw score: 1090
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "F12F6.6" Links |
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Simmer:F12F6.6 Phenotypes |
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Adult |
Ste
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Simmer:F12F6.6 Experiment Details |
Ace View |
Laboratory |
NL |
RNAi Reagent & Type |
sjj_F12F6.6 (PCR_reagent) |
Strain |
NL4256 rrf-3(pk1426) |
Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
Date |
2003-10-01 |
Gene Plot of F12F6.6 |
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