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RNAi Experiment: Simmer:F13D12.7 Ace View of Simmer:F13D12.7
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F13D12.7 (gpb-1)
Description of "F13D12.7"  gpb-1 encodes a heterotrimeric G protein beta subunit that is required during embryonic development for the proper orientation of the mitotic spindle during early cell divisions and thus affects the orientation of early cell division axes, and is also required for larval viability, negatively regulates locomotion and egg-laying, and may affect germline development and osmotic balance; expressed in early embryos with highest expression at cell membranes and colocalizes with asters just before and during early cell divisions (this localization is dependent upon G alpha subunits); adults display high levels of expression in neurons with lower expression in the somatic gonad, vulva, and hypodermal seam cells and expression is also detected in the intestine, pharynx, body wall muscles and in the germline.
KOG Annotation  G-protein beta subunit
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (II:11743943..11746040)
Transcript overlap: 899 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 731
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "F13D12.7" Links  Wormbase NCBI
Simmer:F13D12.7 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 50 - 80 %
Adult  Unc
Simmer:F13D12.7 Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_F13D12.7 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of F13D12.7 Browse using GBrowse
Gene Graph