RNAi Experiment: Simmer:F26D10.3 |
Ace View of Simmer:F26D10.3
|
Genes Inhibited |
|
Gene Inhibited |
F26D10.3 (hsp-1) |
Description of "F26D10.3" |
hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity. |
KOG Annotation  |
Molecular chaperones HSP70/HSC70, HSP70 superfamily
|
|
Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (IV:17279147..17280338)
Transcript overlap: 970 nt |
|
Sliding Window |
Raw score: 928
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.923 |
Wormbase (BLAST) |
RNAi primary |
|
External "F26D10.3" Links |
|
Gene Inhibited |
C15H9.6 (hsp-3) |
Description of "C15H9.6" |
hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum. |
KOG Annotation  |
Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily
|
|
Evidence for Inhibition |
Sliding Window |
Raw score: 77
Relative score: 0.083 (Best raw score= for Gene )
Specificity index: 0.077 |
|
External "C15H9.6" Links |
|
Simmer:F26D10.3 Phenotypes |
|
|
Adult |
Ste
|
Simmer:F26D10.3 Experiment Details |
Ace View |
Laboratory |
NL |
RNAi Reagent & Type |
sjj_F26D10.3 (PCR_reagent) |
Strain |
NL4256 rrf-3(pk1426) |
Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
Date |
2003-10-01 |
Gene Plot of F26D10.3 |
Browse using GBrowse
|
|
Gene Plot of C15H9.6 |
Browse using GBrowse
|
|