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RNAi Experiment: Simmer:F26D10.3 Ace View of Simmer:F26D10.3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  F26D10.3 (hsp-1)
Description of "F26D10.3"  hsp-1 encodes hsp70A, a member of the heat shock family of proteins; hsp70A is closely related to the Drosophila heat inducible hsp70s and the S. cerevisiae SSA hsp70 subfamily; the hsp-1 gene is normally expressed throughout development and upon heat-shock the hsp-1 mRNA is enhanced 2-6 fold; down-regulation of hsp-1 via RNA interference results in a small reduction in the life-span of an age-1 mutant indicating that hsp-1 may play some role in regulating longevity.
KOG Annotation  Molecular chaperones HSP70/HSC70, HSP70 superfamily
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (IV:17279147..17280338)
Transcript overlap: 970 nt		 Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 928
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 0.923
Wormbase (BLAST) RNAi primary
External "F26D10.3" Links  Wormbase NCBI
Gene Inhibited  C15H9.6 (hsp-3)
Description of "C15H9.6"  hsp-3 encodes a heat shock response 70 (hsp70) protein orthologous to human glucose regulated protein 78 (grp78/BiP, OMIM:138120); HSP-3 likely functions as a molecular chaperone, and is expressed constitutively (expression is not heat inducible) throughout development with greatest abundance during the L1 larval stage; HSP-3 contains a long hydrophobic amino terminus and a carboxyl terminal KDEL sequence suggesting that it may be retained in the endoplasmic reticulum.
KOG Annotation  Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily
What's a KOG?
Evidence for Inhibition 
Sliding Window Raw score: 77
Relative score: 0.083 (Best raw score= for Gene )
Specificity index: 0.077
External "C15H9.6" Links  Wormbase NCBI
Simmer:F26D10.3 Phenotypes Help with Phenotypes
Adult  Ste
Simmer:F26D10.3 Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_F26D10.3 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of F26D10.3 Browse using GBrowse
Gene Graph
Gene Plot of C15H9.6 Browse using GBrowse
Gene Graph