Ace View of Simmer:F47F6.1:Repeat_a | |||
Gene Inhibited | F47F6.1 (lin-42) | ||
Description of "F47F6.1" | lin-42 encodes a PAS domain-containing protein orthologous to the insect and mammalian Period proteins that function in the timing of circadian rhythms; during postembryonic development, lin-42 activity is required for the switch from larval to adult fates that occurs in the hypodermal seam cells during the fourth and final molt; as a component of the heterochronic pathway, genetic analysis suggests that lin-42 likely acts early in the heterochronic pathway, either downstream of or in parallel to lin-46, which encodes a predicted scaffolding protein required for L3- and adult-specific cell fates; during larval development, lin-42 mRNA levels oscillate with peak levels apparent during larval intermolts and low levels seen during ecdysis and after the L4-to-adult molt; a rescuing LIN-42::GFP fusion protein is expressed in lateral hypodermal cells, the hypodermal syncytium, and head and tail hypodermal cells beginning during late embryogenesis and continuing through adulthood; within cells, LIN-42 is detected at generally higher levels in nuclei than in cytoplasm, although expression in the latter is enhanced during the larval molts. | ||
Evidence for Inhibition | |||
External "F47F6.1" Links | |||
Adult | Dpy Egl Pvl |
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Laboratory | NL | ||
RNAi Reagent & Type | sjj_F47F6.1 (PCR_reagent) | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Date | 2003-10-01 | ||
Gene Plot of F47F6.1 | |||