| RNAi Experiment: Simmer:F55C7.7:Screen_B |
Ace View of Simmer:F55C7.7:Screen_B
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| Genes Inhibited |
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| Gene Inhibited |
F55C7.7 (unc-73) |
| Description of "F55C7.7" |
The unc-73 gene encodes a guanine nucleotide exchange factor (GNEF) similar to the Trio protein; UNC-73 is required for vulval morphogenesis, for the migration of QL, QR, and hypodermal P cells, the commisure outgrowth of D type motoneurons, and amphid axon outgrowth; UNC-73 has GNEF activity for both CED-10 and MIG-2 in vitro; the requirement for UNC-73 in P cell migration can be suppressed by transgenic overexpression of rho-1; UNC-73 activates several small GTPases: RHO-1 in P cell migration, and both CED-10 and MIG-2 in vulval morphogenesis, P cell migration, and axon outgrowth. |
| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (I:4024285..4025246)
Transcript overlap: 962 nt |
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| Sliding Window |
Raw score: 941
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "F55C7.7" Links |
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| Simmer:F55C7.7:Screen_B Phenotypes |
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| Adult |
Pvl
Stp
Unc
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| Simmer:F55C7.7:Screen_B Experiment Details |
Ace View |
| Laboratory |
NL |
| RNAi Reagent & Type |
sjj_F55C7.7 (PCR_reagent) |
| Strain |
NL4256 rrf-3(pk1426) |
| Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
| Date |
2003-10-01 |
| Gene Plot of F55C7.7 |
Browse using GBrowse
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