| RNAi Experiment: Simmer:K04G2.8:Screen_A |
Ace View of Simmer:K04G2.8:Screen_A
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| Genes Inhibited |
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| Gene Inhibited |
K04G2.8 (apr-1) |
| Description of "K04G2.8" |
The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39. |
| KOG Annotation |
Beta-catenin-binding protein APC, contains ARM repeats
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| Evidence for Inhibition |
| ePCR |
Status: Unique_ePCR (I:8052838..8053985)
Transcript overlap: 1148 nt |
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| Sliding Window |
Raw score: 1127
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
| Wormbase (BLAST) |
RNAi primary |
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| External "K04G2.8" Links |
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| Simmer:K04G2.8:Screen_A Phenotypes |
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| Embryonic |
Emb Penetrance 100 % |
| Larval |
Lva
Lvl
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| Adult |
Bmd
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| Simmer:K04G2.8:Screen_A Experiment Details |
Ace View |
| Laboratory |
NL |
| RNAi Reagent & Type |
sjj_K04G2.8 (PCR_reagent) |
| Strain |
NL4256 rrf-3(pk1426) |
| Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
| Date |
2003-10-01 |
| Gene Plot of K04G2.8 |
Browse using GBrowse
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