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RNAi Experiment: Simmer:K04G2.8:Screen_B Ace View of Simmer:K04G2.8:Screen_B
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  K04G2.8 (apr-1)
Description of "K04G2.8"  The apr-1 gene encodes an ortholog of human APC (OMIM:175100, mutated in familial adenomatous polyposis) that is required for germline fertility, the control of homeodomain expression (CEH-13 and LIN-39) during embryogenesis and vulval development, and for the migration and elongation of hypodermal cells during embryo morphogenesis; APR-1 is thought to reside in adherens junctions, while also stimulating two beta-catenins in Wnt signalling (HMP-2 in migrating epithelial cells, and BAR-1 in the vulval precursor cells); however, APR-1 also binds PRY-1/axin, and with PRY-1 inhibits RAS-independent Wnt induction of LIN-39.
KOG Annotation  Beta-catenin-binding protein APC, contains ARM repeats
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:8052838..8053985)
Transcript overlap: 1148 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1127
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "K04G2.8" Links  Wormbase NCBI
Simmer:K04G2.8:Screen_B Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 90 %
Larval  Lvl
Simmer:K04G2.8:Screen_B Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_K04G2.8 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of K04G2.8 Browse using GBrowse
Gene Graph