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RNAi Experiment: Simmer:R05D11.3:Screen_A Ace View of Simmer:R05D11.3:Screen_A
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  R05D11.3 (ran-4)
Description of "R05D11.3"  ran-4 encodes a ortholog of NUCLEAR TRANSPORT FACTOR 2 (NTF2) from S. cerevisiae and metazoa, which is predicted to interact with nucleoporins and to promote transport of RAN-1(+GDP) into the nucleus; RAN-4/NTF2 proteins are paralogous to the N-terminal domain of RasGAP SH3 binding proteins such as Drosophila RASPUTIN, and to delta-5-3-ketosteroid isomerases, while having no homology to Ran proteins per se; RAN-4 is essential for early embryogenesis; in mass RNAi assays, ran-4 is needed for embryonic viability, normally rapid growth, fertility, and normal pronuclear envelopes in the embryo.
KOG Annotation  Nuclear transport factor 2
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:8590897..8591819)
Transcript overlap: 487 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 403
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "R05D11.3" Links  Wormbase NCBI
Simmer:R05D11.3:Screen_A Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 90 %
Larval  Lva
Adult  Unc
Simmer:R05D11.3:Screen_A Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_R05D11.3 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of R05D11.3 Browse using GBrowse
Gene Graph