Ace View of Simmer:R06C7.8:Screen_A | |||
Gene Inhibited | R06C7.8 (bub-1) | ||
Description of "R06C7.8" | bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages. | ||
KOG Annotation  | Mitotic checkpoint serine/threonine protein kinase |
||
Evidence for Inhibition | |||
External "R06C7.8" Links | |||
Embryonic | Emb Penetrance 100 % | ||
Adult | Stp Unc |
||
Laboratory | NL | ||
RNAi Reagent & Type | sjj_R06C7.8 (PCR_reagent) | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Date | 2003-10-01 | ||
Gene Plot of R06C7.8 | |||