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RNAi Experiment: Simmer:T01B11.3 Ace View of Simmer:T01B11.3
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T01B11.3 (syn-4)
Description of "T01B11.3"  syn-4 encodes a Type-I transmembrane protein that is orthologous to mammalian Syntaxin 1, a t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor); by homology, SYN-4 is predicted to function as a receptor for intracellular transport vesicles during membrane fusion reactions; in C. elegans, SYN-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYN-4 may also play a role in formation of the vitelline membrane and/or eggshell; SYN-4 is expressed in the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYN-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYN-4 localizes to the incomplete membranes that separate germline nuclei in the gonad.
KOG Annotation  SNARE protein Syntaxin 1 and related proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (IV:8457268..8458725)
Transcript overlap: 789 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 684
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "T01B11.3" Links  Wormbase NCBI
Simmer:T01B11.3 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 50 - 80 %
Simmer:T01B11.3 Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_T01B11.3 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of T01B11.3 Browse using GBrowse
Gene Graph