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RNAi Experiment: Simmer:T23D8.9:Screen_A Ace View of Simmer:T23D8.9:Screen_A
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  T23D8.9 (sys-1)
Description of "T23D8.9"  sys-1 encodes a novel protein that contains three divergent armadillo repeats; during gonadogenesis, SYS-1 functions in a Wnt/MAPK signaling pathway as a dosage-dependent beta-catenin-like transcriptional coactivator required for specification of distal cell fates; consistent with its role as a beta-catenin, SYS-1 interacts, in yeast two-hybrid and coimmunoprecipitation assays, with the POP-1/TCF transcription factor with which it can stimulate transcription via TCF binding sites; in two hybrid-assays, the POP-1/SYS-1 interaction requires the N-terminal beta-catenin binding domain of POP-1, and most of the SYS-1 protein; the SYS-1 expression pattern is not yet known.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:9982040..9983132)
Transcript overlap: 944 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 818
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "T23D8.9" Links  Wormbase NCBI
Simmer:T23D8.9:Screen_A Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 100 %
Adult  Bmd
Pvl
Rup
Stp
Unc
Simmer:T23D8.9:Screen_A Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_T23D8.9 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of T23D8.9 Browse using GBrowse
Gene Graph