RNAi Experiment: Simmer:W02A11.4:Screen_A |
Ace View of Simmer:W02A11.4:Screen_A
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Genes Inhibited |
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Gene Inhibited |
W02A11.4 (uba-2) |
Description of "W02A11.4" |
uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation. |
KOG Annotation  |
SMT3/SUMO-activating complex, catalytic component UBA2
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (I:12741427..12743648)
Transcript overlap: 742 nt |
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Sliding Window |
Raw score: 616
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "W02A11.4" Links |
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Simmer:W02A11.4:Screen_A Phenotypes |
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Larval |
Lva
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Adult |
Pvl
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Simmer:W02A11.4:Screen_A Experiment Details |
Ace View |
Laboratory |
NL |
RNAi Reagent & Type |
sjj_W02A11.4 (PCR_reagent) |
Strain |
NL4256 rrf-3(pk1426) |
Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
Date |
2003-10-01 |
Gene Plot of W02A11.4 |
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