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RNAi Experiment: Simmer:W02A11.4:Screen_B Ace View of Simmer:W02A11.4:Screen_B
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  W02A11.4 (uba-2)
Description of "W02A11.4"  uba-2 encodes the C. elegans ortholog of Saccharomyces cerevisiae Uba2p and human ubiquitin-like 2 activating enzyme E1B; by homology, UBA-2 is predicted to form, with a regulatory subunit, AOS-1, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, UBA-2 is required for embryogenesis and vulval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation.
KOG Annotation  SMT3/SUMO-activating complex, catalytic component UBA2
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (I:12741427..12743648)
Transcript overlap: 742 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 616
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "W02A11.4" Links  Wormbase NCBI
Simmer:W02A11.4:Screen_B Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 20 - 40 %
Larval  Lva
Adult  Pvl
Stp
Unc
Simmer:W02A11.4:Screen_B Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_W02A11.4 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of W02A11.4 Browse using GBrowse
Gene Graph