RNAi Experiment: Simmer:W05E10.3 |
Ace View of Simmer:W05E10.3
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Genes Inhibited |
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Gene Inhibited |
W05E10.3 (ceh-32) |
Description of "W05E10.3" |
ceh-32 encodes a Six/sine oculis-type homeodomain protein most closely related to the Six3/6 subfamily that contains Drosophila OPTIX and human SIX3 (OMIM:603714, which when mutated leads to holoprosencephaly 2); CEH-32 appears to be essential for development and required for proper head morphogenesis; during embryogenesis, CEH-32 is expressed in hypodermal and neuronal precursors, and at later stages, in the descendants of these cells and in gonadal sheath cells; in some hypodermal cells, ceh-32 is a direct transcriptional target of VAB-3, a PAX-6 ortholog sufficient to induce ceh-32 expression in some cell types and able to bind the ceh-32 promoter in vitro. |
KOG Annotation  |
Transcription factor SIX and related HOX domain proteins
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (V:11704667..11706090)
Transcript overlap: 1037 nt |
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Sliding Window |
Raw score: 995
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "W05E10.3" Links |
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Simmer:W05E10.3 Phenotypes |
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Embryonic |
Emb Penetrance 20 - 40 % |
Larval |
Lva
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Adult |
Unc
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Simmer:W05E10.3 Experiment Details |
Ace View |
Laboratory |
NL |
RNAi Reagent & Type |
sjj_W05E10.3 (PCR_reagent) |
Strain |
NL4256 rrf-3(pk1426) |
Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
Date |
2003-10-01 |
Gene Plot of W05E10.3 |
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