Ace View of Simmer:Y38A8.2 | |||
Gene Inhibited | Y38A8.2 (pbs-3) | ||
Description of "Y38A8.2" | pbs-3 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-3 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-3 activity via large-scale RNAi screens indicates that, in C. elegans, PBS-3 is required for embryonic and germline development, movement, normal body coloration, and normal body morphology. | ||
KOG Annotation  | 20S proteasome, regulatory subunit beta type PSMB3/PUP3 |
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Evidence for Inhibition | |||
External "Y38A8.2" Links | |||
Embryonic | Emb Penetrance 100 % | ||
Laboratory | NL | ||
RNAi Reagent & Type | sjj_Y38A8.2 (PCR_reagent) | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Date | 2003-10-01 | ||
Gene Plot of Y38A8.2 | |||