RNAi Experiment: Simmer:Y47D3B.7 |
Ace View of Simmer:Y47D3B.7
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Genes Inhibited |
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Gene Inhibited |
Y47D3B.7 (sbp-1) |
Description of "Y47D3B.7" |
sbp-1 encodes a basic helix-loop-helix (bHLH) transcription factor homologous to the mammalian Sterol Regulatory Element Binding Proteins (SREBPs, OMIM:184756, overexpression of nuclear form of SREBP-1c is associated with insulin resistance and features of congenital generalized lipodystrophy); in C. elegans, SBP-1 activity is required for normal lipid metabolism and wild-type levels of lipogenic enzyme expression, as well as for embryonic and larval development; sbp-1 expression is detected exclusively in the intestine, the major site of fat storage, from early embryogenesis through adulthood. |
KOG Annotation  |
Predicted DNA-binding protein
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Evidence for Inhibition |
ePCR |
Status: Unique_ePCR (III:11436788..11437719)
Transcript overlap: 779 nt |
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Sliding Window |
Raw score: 698
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene) |
Wormbase (BLAST) |
RNAi primary |
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External "Y47D3B.7" Links |
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Simmer:Y47D3B.7 Phenotypes |
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Larval |
Lva
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Simmer:Y47D3B.7 Experiment Details |
Ace View |
Laboratory |
NL |
RNAi Reagent & Type |
sjj_Y47D3B.7 (PCR_reagent) |
Strain |
NL4256 rrf-3(pk1426) |
Reference |
Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." |
Date |
2003-10-01 |
Gene Plot of Y47D3B.7 |
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