Ace View of Simmer:Y48G1A_54.b:Screen_A | |||
Gene Inhibited | Y48G1A.5 (imb-5) | ||
Description of "Y48G1A.5" | imb-5 encodes an importin-beta-like protein orthologous to mammalian CAS proteins (cellular apoptosis susceptibility) and Saccharomyces cerevisiae CSE1 (chromosome segregation 1); IMB-5 is predicted to function in nuclear transport of proteins required for mitotic progression or apoptosis as well as in re-export of importin-alpha, a nuclear import protein; in C. elegans, IMB-5 is essential for embryogenesis and required for normal pronuclear envelope dynamics, and may also play a role in vulval morphogenesis. | ||
KOG Annotation  | Nuclear export receptor CSE1/CAS (importin beta superfamily) |
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Evidence for Inhibition | |||
External "Y48G1A.5" Links | |||
Embryonic | Emb Penetrance 100 % | ||
Adult | Sck Ste brood size (6 out of 10) Unc |
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Laboratory | NL | ||
RNAi Reagent & Type | sjj_Y48G1A_54.b (PCR_reagent) | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Date | 2003-10-01 | ||
Gene Plot of Y48G1A.5 | |||