Ace View of Simmer:ZK1151.1:Screen_A | |||
Gene Inhibited | ZK1151.1 (vab-10) | ||
Description of "ZK1151.1" | vab-10 encodes, by alternative splicing, two spectraplakins (VAB-10A and VAB-10B) that are jointly required for mechanical resilience of the epidermis under strain by the contraction of actin microfilaments mechanically linked to fibrous organelles (FOs); VAB-10A/B are, accordingly, required for elongation during embryonic morphogenesis; VAB-10A has C-terminal plectin repeats while VAB-10B has spectrin repeats; VAB-10A is required to keep the epidermis and extracellular matrix attached via FOs, while VAB-10B is required to keep the apical and basal epidermal plasma membranes connected during morphogenesis; vab-10a and vab-10b mutations complement one another; vab-10 is orthologous to human BPAG1 (dystonin or MACF2, OMIM:113810, encoding an autoantigen of bullous pemphigoid blistering disease) and dJ562N20.1 (MACF1), and to Drosophila SHORT STOP. | ||
KOG Annotation  | Dystonin, GAS (Growth-arrest-specific protein), and related proteins |
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Evidence for Inhibition | |||
External "ZK1151.1" Links | |||
Adult | Pvl Rup Ste |
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Phenotype | Prz |
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Laboratory | NL | ||
RNAi Reagent & Type | sjj_ZK1151.1 (PCR_reagent) | ||
Strain | NL4256 rrf-3(pk1426) | ||
Reference | Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...." | ||
Date | 2003-10-01 | ||
Gene Plot of ZK1151.1 | |||