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RNAi Experiment: Simmer:ZK617.1 Ace View of Simmer:ZK617.1
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  ZK617.1 (unc-22)
Description of "ZK617.1"  unc-22 encodes twitchin, a giant intracellular protein with multiple fibronectin- and immunoglobulin-like domains and a single protein kinase domain that is homologous to titin (OMIM:188840); UNC-22 is required in muscle for regulation of the actomyosin contraction-relaxation cycle and for maintenance of normal muscle morphology; UNC-22 associates with myosin and is localized to A-bands; in vitro, UNC-22 can phosphorylate myosin light-chain peptides and can undergo autophosphorylation.
KOG Annotation  Projectin/twitchin and related proteins
What's a KOG?
Evidence for Inhibition 
ePCR Status: Unique_ePCR (IV:11987289..11988439)
Transcript overlap: 1151 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 1151
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "ZK617.1" Links  Wormbase NCBI
Simmer:ZK617.1 Phenotypes Help with Phenotypes
Adult  Unc
Phenotype  Prz
Simmer:ZK617.1 Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_ZK617.1 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of ZK617.1 Browse using GBrowse
Gene Graph