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RNAi Experiment: Simmer:ZK637.8 Ace View of Simmer:ZK637.8
Genes Inhibited How is RNAi inhibition determined?
Gene Inhibited  ZK637.8 (unc-32)
Description of "ZK637.8"  unc-32 encodes six isoforms of a highly conserved vacuolar H+-ATPase a subunit (V-ATPase) homologous to the vertebrate a1 proteins that have been implicated in a number of human diseases including osteopetrosis (OMIM:259700); UNC-32 is predicted to function as part of an ATP-dependent proton pump that regulates acidification of intracellular compartments and is essential for locomotion and embryonic and larval development; UNC-32 is expressed throughout the life cycle, with early and broad expression detectable in the embryo, and larval and adult expression detectable in the gut, gonad, and neurons.
Evidence for Inhibition 
ePCR Status: Unique_ePCR (III:8908099..8908955)
Transcript overlap: 857 nt
Explain types of evidence for RNAi inhibition
Sliding Window Raw score: 836
Relative score: 1 (This gene has the best score for this RNAi reagent)
Specificity index: 1 (RNAi reagent is specific for this gene)
Wormbase (BLAST) RNAi primary
External "ZK637.8" Links  Wormbase NCBI
Simmer:ZK637.8 Phenotypes Help with Phenotypes
Embryonic  Emb Penetrance 100 %
Larval  Gro
Adult  Unc
Simmer:ZK637.8 Experiment Details Ace View
Laboratory  NL
RNAi Reagent & Type  sjj_ZK637.8 (PCR_reagent)
Strain  NL4256 rrf-3(pk1426)
Reference  Simmer F et al. (2003) PLoS Biology "Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals ...."
Date  2003-10-01
Gene Plot of ZK637.8 Browse using GBrowse
Gene Graph